Mosconi, L., Brinton, RD. How would we combat menopause as an Alzheimer’s risk factor? Expert Rev Neurother. 2018 Aug 9. doi: 10.1080/14737175.2018.1510320. [Epub ahead of print]

Karim, R., Koc, M., Rettberg, JR., Hodis, HN., Henderson, VW., St John, JA., Allayee, H., Brinton, RD., Mack, WJ. Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer’s disease. Menopause. 2018, Jul 2. doi: 10.1097/GME.0000000000001160. [Epub ahead of print]

Chen, S., Kumar, N., Mao, Z., Sitruk-Ware, R., Brinton, RD. Therapeutic progestin segesterone acetate promotes neurogenesis: implications for sustaining regeneration in female brain. Menopause. 2018, May 29. doi: 10.1097/GME.0000000000001135. [Epub ahead of print]

Hernandez, G., Zhao, L., Franke, AA., Mack, WJ., Brinton, RD., Schneider, LS. Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor β -selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause. 2018 Feb;25(2):191-196. doi: 10.1097/GME.0000000000000984

Geifman, N., Kennedy R.E., Schneider L.S., Buchan, I., Brinton RD. Data-driven identification of endophenotypes of Alzheimer’s disease progression: implications for clinical trials and therapeutic interventions. Alzheimer's Research & Therapy, 2018 Jan 15;10(1). doi: 10.1186/s13195-017-0332-0

Wang JY, Trivedi AM, Carrillo NR, Yang J, Schneider A, Giulivi C, Adams P, Tassone F, Kim K, Rivera SM, Lubarr N, Wu CY, Irwin RW, Brinton RD, Olichney JM, Rogawski MA, Hagerman RJ. Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome. Neurotherapeutics. 2017 Oct;14(4):1073-1083. doi: 10.1007/s13311-017-0555-6

Mosconi L, Berti V, Guyara-Quinn C, McHugh P, Petrongolo G, Osorio RS, Connaughty C, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Swerdlow RH, Brinton RD. Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PLoS One. 2017 Oct 10;12(10): e0185926. doi: 10.1371/journal.pone.0185926

Mosconi L, Berti V, Quinn C, McHugh P, Petrongolo G, Varsavsky I, Osorio RS, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD. Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging. Neurology. 2017 Sep 26;89(13):1382-1390. doi: 10.1212/WNL.0000000000004425. Epub 2017 Aug 30

Yin F, Yao J, Brinton RD, Cadenas E. Editorial: The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration. Front Aging Neurosci. 2017 Jun 28;9:209. doi: 10.3389/fnagi.2017.00209. eCollection 2017

Geifman N, Brinton RD, Kennedy RE, Schneider LS, Butte AJ. Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease. Alzheimers Res Ther. 2017 Feb 17;9(1):10. doi: 10.1186/s13195-017-0237-y

Zissimopoulos J, Barthold D, Brinton R, Joyce G, Sex and Race Differences in the Association of Statin Use and Incidence of Alzheimer’s Disease JAMA Neurol. 2017 Feb 1; 74(2): 225-232. doi: 10.1001/jamaneurol.2016.3783

Karim R, Dang H, Henderson VW, Hodis HN, St John J, Brinton RD, Mack WJ. Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life. J Am Geriatr Soc. 2016 Dec;64(12):2448-2456. doi: 10.1111/jgs.14658. PMCID: PMC5180359

Zissimopoulos JM, Barthold D, Brinton RD, Joyce G. Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease. JAMA Neurol. 2016 Dec 12. doi: 10.1001/jamaneurol.2016.3783. PMID:27942728

Brinton RD Neuroendocrinology: Oestrogen therapy affects brain structure but not function. Nat Rev Neurol. 2016 Sep 28;12(10):561-2. doi: 10.1038/nrneurol.2016.147. PMID:27677967

Yiwei Wang, Roberta D. Brinton Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex.Frontiers in Aging Neuroscience Front Aging Neurosci. 2016 Oct 4;8:232. Review. PMID:27757081

Zhao L, Mao Z, Woody SK, Brinton RD. Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease. Neurobiol Aging. 2016 Jun;42:69-79. doi: 10.1016/j.neurobiolaging.2016.02.011. Epub 2016 Feb 18.

Rettberg JR, Dang H, Hodis HN, Henderson VW, St John JA, Mack WJ, Brinton RD. Identifying postmenopausal women at risk for cognitive decline within a healthy cohort using a panel of clinical metabolic indicators: potential for detecting an at-Alzheimer's risk metabolic phenotype. Neurobiol Aging. 2016 Apr;40:155-63. doi: 10.1016/j.neurobiolaging.2016.01.011. Epub 2016 Jan 29.
PMID: 26973115 

Riedel BC, Thompson PM, Brinton RD. Age, APOE and sex: Triad of risk of Alzheimer's disease. J Steroid Biochem Mol Biol. 2016 Mar 8. pii: S0960-0760(16)30058-9. doi: 10.1016/j.jsbmb.2016.03.012. [Epub ahead of print] Review.
PMID: 26969397

Lauren P. Klosinski, Jia Yao, Fei Yin, Alfred N. Fonteh, Michael G. Harrington, Trace A. Christensen, Eugenia Trushina, Roberta Diaz Brinton. White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease. Published Online: November 11, 2015. DOI:

Espeland MA, Brinton RD, Hugenschmidt C, Manson JE, Craft S, C Yaffe, Weitlauf J, Vaughan L, Johnson KC, Padula CB, RD Jackson, Resnick SM. Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women. Diabetes Care. 2015 Oct 20. pii: dc151385. [Epub ahead of print]

Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM; WHIMS-MRI2 Study Group. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology. 2015 Jul 10. pii: 10.1212/WNL.0000000000001816. PMID: 26163429

Irwin RW, Solinsky CM, Loya CM, Salituro FG, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease. PLoS One. 2015 Jun 3;10(6):e0128313. doi: 10.1371/journal.pone.0128313. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0132210. PMID: 26039057 

Brinton RD, Yao J, Yin F, Mack WJ, Cadenas E. Perimenopause as a neurological transition state. Nat Rev Endocrinol. 2015 Jul;11(7):393-405. doi: 10.1038/nrendo.2015.82. Epub 2015 May 26. Review. PMID: 26007613

Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity.Neurobiol Aging. 2015 Jul;36(7):2282-95. doi: 10.1016/j.neurobiolaging.2015.03.013. Epub 2015 Apr 1. PMID: 25921624

Caldwell CC, Yao J, Brinton RD. Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities. Neurotherapeutics. 2015 Jan;12(1):66-80. doi: 10.1007/s13311-014-0324-8. PMID: 25534394

Karim R, Stanczyk FZ, Brinton RD, Rettberg J, Hodis HN, Mack WJ. Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women. J Clin Endocrinol Metab. 2015 Feb;100(2):508-15. doi: 10.1210/jc.2014-1839. Epub 2014 Nov 18. PMID: 25405497

Irwin RW, Solinsky CM, Brinton RD. Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders. Front Cell Neurosci. 2014 Jul 30;8:203. doi: 10.3389/fncel.2014.00203. eCollection 2014. Review. PMID: 25126056

Irwin RW, Brinton RD. Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise. Prog Neurobiol. 2014 Feb;113:40-55. doi: 10.1016/j.pneurobio.2013.08.004. Epub 2013 Sep 14. Review. PMID: 24044981 

Rettberg JR, Yao J, Brinton RD. Estrogen: a master regulator of bioenergetic systems in the brain and body.

Front Neuroendocrinol. 2014 Jan;35(1):8-30. doi: 10.1016/j.yfrne.2013.08.001. Epub 2013 Aug 29. Review. PMID: 23994581 

Brinton, RD Neurosteroids as Regenerative Agents in Brain: Therapeutic Implications, 2013 Apr; 9(4):241-50. doi: 10.1038/nrendo.2013.31. Epub 2013 Feb 26. PMID:23438839 

Yao J, Zhao L, Mao Z, Chen S, Wong K, To J, Brinton RD. Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments. Brain Res. 2013 Feb 18. pii: S0006-8993(13)00235-7. doi: 10.1016/j.brainres.2013.02.021. PMID:23428542

Ding F, Yao J, Zhao L, Mao Z, Chen S, Brinton RD.  Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's. PLoS One. 2013;8(3):e59825. doi: 10.1371/journal.pone.0059825. Epub 2013 Mar 26. PMCID:PMC3608536

Singh M, Simpkins JW, Simpkins JW, Bimonte-Nelson HA, Bimonte-Nelson HA, Brinton RD. Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease.Brain Res. 2013 Jun 13;1514:1-2. doi: 10.1016/j.brainres.2013.04.044. PMID:23726132

Jiang T, Yin F, Yao J, Brinton RD, Cadenas E. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1alpha transcriptional pathway.   Aging Cell. 2013 Dec;12(6):1021-31. doi: 10.1111/acel.12127. Epub 2013 Jul 29 PMID:23815272

Sancheti H, Akopian G, Yin F, Brinton RD, Walsh JP, Cadenas E. Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic Acid on a mouse model of Alzheimer's disease. PLoS One. 2013 Jul 17;8(7):e69830. doi: 10.1371/journal.pone.0069830. Print 2013.
Ding F, Yao J, Rettberg JR, Chen S, Brinton RD. Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for   bioenergetic intervention. PLoS One. 2013 Nov 11;8(11):e79977. doi: 10.1371/journal.pone.0079977. eCollection 2013. PMID:24244584

Irwin RW, Brinton RD Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise. Prog Neurobiol. 2014 Feb;113:40-55. doi: 10.1016/j.pneurobio.2013.08.004. Epub 2013 Sep 14. PMID: 24044981

Fuente-Martin E, Garcia-Caceres C, Morselli E, Clegg DJ, Chowen JA, Finan B, Brinton RD, Tschöp MH. Estrogen, astrocytes and the neuroendocrine control of metabolism. Rev Endocr Metab Disord. 2013 Dec;14(4):331-8. doi: 10.1007/s11154-013-9263-7. PMID:24009071

Rettberg JR, Yao J, Brinton RD. Estrogen: a master regulator of bioenergetic systems in the brain and body. Front Neuroendocrinol. 2014 Jan;35(1):8-30. doi: 10.1016/j.yfrne.2013.08.001. Epub 2013 Aug 29

Zhao L, Mao Z, Chen S, Schneider LS, Brinton RD. Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease. J Alzheimers Dis. 2013;37(2):403-19. doi: 10.3233/JAD-122341. PMID:23948892 PMID:23994581

Irwin R, Yao J,To, Hamilton R, Cadena E, Brinton R. Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function. J Neuroendocrinol. 2012 Jan;24(1):236-48. PMID: 22070562

Irwin R., Wang JM, Chen S., and Brinton RD. Neuroregenerative mechanisms of allopregnanolone in Alzheimer’s disease Front. Endocrinol., 12 January 2012 | doi: 10.3389/fendo.2011.00117 PMCID:PMC3356095

Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One. 2012;7(2):e31267. Epub 2012 Feb 29. PMID: 22393359

Bali N, Arimoto JM, Iwata N, Lin SW, Zhao L, Brinton RD, Morgan TE, Finch CE Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.
Endocrinology. 2012 Feb;153(2):759-69. Epub 2011 Dec 6 PMID: 22147012

Wang JM, Hou X, Adeosun S, Hill R, Henry S, Paul I, Irwin RW, Ou XM, Bigler S, Stockmeier C, Brinton RD,
Gomez-Sanchez E. A Dominant Negative ERβ Splice Variant Determines the Effectiveness of Early or Late Estrogen Therapy after Ovariectomy in Rats. PLoS One. 2012;7(3):e33493. Epub 2012 Mar 13. PMID: 22428062

Sun C, Ou X, Farley JM, Stockmeier C, Bigler S, Brinton RD, Wang JM. Allopregnanolone Increases the Number of Dopaminergic Neurons in Substantia Nigra of a Triple Transgenic Mouse Model of Alzheimer’s Disease J Curr Alzheimer Res. 2012 May 1; 9(4): 473–480. PMCID: PMC3348519

Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ.17β-Estradiol and Progesterone Regulate Expression of β-Amyloid Clearance Factors in Primary Neuron Cultures and Female Rat Brain. Endocrinology. 2012 Sep 7. [Epub ahead of print] PMID: 22962256

Yao J, Brinton RD. Estrogen Regulation of Mitochondrial Bioenergetics: Implications for Prevention of Alzheimer's Disease. Adv Pharmacol. 2012;64:327-71. PMID: 22840752

Reiman EM, Brinton RD, Katz R, Petersen RC, Negash S, Mungas D, Aisen PS. Considerations in the design of clinical trials for cognitive aging. J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):766-72. Epub 2012 May 9. Review. PMID: 22573913

Samuel O. Adeosun, Xu Hou, Yun Jiao, Baoying Zheng, Sherry Henry, Rosanne Hill, Zhi He,Amar Pani, Patrick Kyle, Xiaoming Ou, Thomas Mosley, Jerry M. Farley, Craig Stockmeier, Ian Paul, Steven Bigler, Roberta Diaz Brinton, Richard Smeyne , Jun Ming Wang Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease PLoS One. 2012;7(11):e50040. doi: 10.1371/journal.pone.0050040. Epub 2012 Nov 29. PMCID:PMC3510204

Singh C, Liu L, Wang JM, Irwin RW, Yao J, Chen S, Henry S, Thompson RF, Brinton RD. Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice.Neurobiol Aging.2012 Aug;33(8):1493-506. Epub 2011 Jul 30. PMCID:PMC3232295

Aisen P, Albert M, Carrillo M, Diaz-Brinton R, Davies P, DeKosky S, Fillit H, Goate A, Hodes R, Khachaturian AS, Khachaturian ZS, Jack CR, Mucke L, Nixon RA, Paul S, Petersen RC, Potter W, Reiman E, Schenk D, Thies W, Gallagher-Thompson D, Yaffe K Workgroup on NAPA's scientific agenda for a national initiative on Alzheimer's disease.Alzheimers Dement. 2012 Jul;8(4):357-71. doi: 10.1016/j.jalz.2012.04.003. Alzheimer's Association Expert Advisory Workgroup on NAPA.

Brinton RD. Minireview: translational animal models of human menopause: challenges and emerging opportunities.Endocrinology. 2012 Aug;153(8):3571-8. doi: 10.1210/en.2012-1340. Epub 2012 Jul 9. Review .PMID: 22778227

Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: Implication for a therapeutic window of opportunity. Brain Res. 2011 Mar 16;1379:11-22. Epub 2011 Jan 15 PMID: 21241683

Wu TW, Chen S, Brinton RD. Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons. Brain Res. 2011 Mar 16;1379:34-43. Epub 2011 Jan 15. PMID: 21241678

Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Res. 2011 Mar 16;1379:23-33. Epub 2011 Jan 14. PMID: 21238431

Irwin RW, Yao J, Ahmed SS, Hamilton RT, Cadenas E, Brinton RD. Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology. 2011 Feb;152(2):556-67. Epub 2010 Dec 15. PMID: 21159850

Yao J, Irwin RW, Chen S, Hamilton R, Cadenas E, Brinton RD. Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid Neurobiol Aging. .2012 Aug;33(8):1507-21. Epub 2011 Apr 22. PMCID:PMC3181273

Yao J, Chen S, Mao Z, Cadenas E, Brinton RD. 2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One. 2011;6(7):e21788. Epub 2011 Jul 1 PMCID:PMC3128612

Clarkson TB, Barnes S, Brinton RD. etal The role of soy isoflavones in menopausal health: report of The North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010). Menopause. 2011 Jul;18(7):732-53. PMID: 21685820

Zhao L, Mao Z, Schneider LS, Brinton RD. Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause. Menopause. 2011 Oct;18(10):1131-42.PMID: 21738079

Chen S, Wang JM, Irwin RW, Yao J, Liu L, Brinton RD. Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. PLoS One. 2011;6(8):e24293. Epub 2011 Aug 30. PMID: 21918687

Yao J, Brinton RD. Targeting Mitochondrial Bioenergetics for Alzheimer's Prevention and Treatment. Curr Pharm Des. 2011;17(31):3474-9. PMID:21902662

Yao, J., Rettberg, J.R., Klosinski, L.P. Cadenas, E and Brinton, R.D.  Shift in brain metabolism in late onset Alzheimer's disease: Implications for biomarkers and therapeutic interventions. Mol Aspects Med. 2011 Aug;32(4-6):247-57. Epub 2011 Oct 21. PMID: 22024249

Bali N, Arimoto JM, Iwata N, Lin SW, Zhao L, Brinton RD, Morgan TE, Finch CE. Differential Responses of Progesterone Receptor Membrane Component-1 (Pgrmc1) and the Classical Progesterone Receptor (Pgr) to 17β-Estradiol and Progesterone in Hippocampal Subregions that Support Synaptic Remodeling and Neurogenesis.  Endocrinology. 2011 Dec 6. [Epub ahead of print]. PMID: 22147012

Irwin RW, Yao J, To J, Hamilton RT, Cadenas E, Brinton RD. Selective Oestrogen Receptor Modulators Differentially Potentiate Brain Mitochondrial Function. J Neuroendocrinol.2012 Jan;24(1):236-48. doi: 10.1111/j.1365-2826.2011.02251.x. PMCID:PMC3264398

Wang JM, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD, (2010) Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6498-503. Epub 2010 Mar 15. Proc Natl Acad Sci USA. 2010 Jun 15;107(24):11145.  PMID: 20231471

Yao, J., Hamilton, RT, Cadenas, E. Brinton RD, (2010) Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence, Biochim Biophys Acta. 2010 Oct:1800 (10):1121-6 Epub 2010PMID 20538040 

Henderson VW, Brinton RD, (2010) Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy. Prog Brain Res. 2010;182:77-96. PMID: 20541661

Zhao L, Yao J, Mao Z, Chen S, Wang Y, Brinton RD, (2010) 17beta-Estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: Relevance to Alzheimer's prevention. Neurobiol Aging. 2010 Jan 4Epub ahead of print. PMID: 20053478

Liu L, Zhao L, She H, Chen S, Wang JM, Wong C, McClure K, Sitruk-Ware R., Brinton RD., (2010) Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo. Endocrinology. 2010 Dec;151(12):5782-94. Epub 2010 Oct 13. PMID: 20943809

Jia Yao, Ronald W. Irwin, Liqin Zhao, Jon Nilsen, Ryan T. Hamilton, and Roberta Diaz Brinton. Mitochondrial bioenergetic deficit precedes Alzheimer’s pathology in female mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14670-5. Epub 2009 Aug 10. PMC2732886.

Roberta Diaz Brinton. Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends Pharmacol Sci. 2009 Apr;30(4):212-22. Epub 2009 Mar 18. Review.PMID: 19299024.

Liqin Zhao, Zisu Mao, and Roberta Diaz Brinton. A Select Combination of Clinically Relevant Phytoestrogens Enhances Estrogen Receptor-Binding Selectivity and Neuroprotective Activities in Vitro and in Vivo. Endocrinology, February 2009, 150(2):770–783. PMID: 18818291.

Asthana S, Brinton RD, Henderson VW, McEwen B, Morrison J, Schmidt P. Frontiers proposal. National Institute on Aging "bench to bedside: estrogen as a case study." Age (Dordr). 2009 Sep;31(3):199–210. Epub 2009 Mar 10. PMC2734241.

Lifei Liu, Junming Wang, Liqin Zhao, Jon Nilsen, Kelsey McClure, Karren Wong and Roberta Diaz Brinton. Progesterone Increases Rat Neural Progenitor Cell Cycle Gene Expression and Proliferation Via Extracellularly Regulated Kinase and Progesterone Receptor Membrane Components 1 and 2 Endocrinology. 2009 Jul;150(7):3186-96. Epub 2009 Apr 9. PMC2703530.

Brinton, RD. The Healthy Cell Bias of Estrogen Action: Mitochondrial Bioenergetics and Neurological Implications. Trends Neurosci. 2008 Oct;31(10):529-37. Epub 2008 Sep 4. Review. PMID: 18774188.

Wang JM, Liu L, Brinton RD. Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway. Endocrinology. 2008 Jan;149(1):208-18. Epub 2007 Oct 25. PMC2734499.

Brinton, RD. Estrogen regulation of glucose metabolism and mitochondrial function: Therapeutic implications for prevention of Alzheimer's disease. Adv Drug Deliv Rev. 2008 Oct-Nov;60 (13-14):1504-11. Epub 2008 Jul 4. Review. PMID: 18647624.

Wang JM, Brinton RD. Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential. BMC Neuroscience 2008, Dec 3;9(Suppl 2):S11 PMC2604895.

Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen JProgesterone receptors: form and function in brain. Front Neuroendocrinol. May;29(2):313-39. Epub 2008 Feb 23. Review. PMC2398769.

Irwin RW, Yao J, Hamilton R, Cadenas E, Brinton RD, Nilsen J Progesterone and Estrogen Regulate Oxidative Metabolism in Brain Mitochondria. Endocrinology. 2008 Jun;149(6):3167-75. Epub 2008 Feb 21. PMC2408802.

Wang JM, Liu L, Irwin RW, Chen S, Brinton RD. Regenerative Potential of Allopregnanolone. Brain Res Rev. 2008 Mar;57(2):398-409. Epub 2007 Sep 14. Review. PMID: 17931704.

Nilsen J, Irwin RW, Gallaher TK, Brinton RD. Estradiol in vivo regulation of brain mitochondrial proteome. J Neurosci 27:14069-14077. PMID: 18094246

Zhao L, Jin C, Mao Z, Gopinathan MB, Rehder K, Brinton RD.  Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons. J Med Chem 50:4471-4481. PMID: 17696335

Liqin Zhao, Brinton RD. WHI And WHIMS Followup And Human Studies of Soy Isoflavones On Cognition. Expert Rev. Neurotherapeutics 2007 7 (11) 1549-1564.

Brinton RD. Building A Neuroscience Legacy. J Neurosci 27:11163-11166. PMID: 17942709

Soussou WV, Yoon GJ, Brinton RD, Berger TW   Neuronal network morphology and electrophysiologyof hippocampal neurons cultured on surface-treated multielectrode arrays. IEEE Trans Biomed Eng 54:1309-1320. PMID: 17605362

Wang JM, Irwin RW, Liu L, Chen S, Brinton RD. Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent. Curr Alzheimer Res 4:510-517. PMID: 18220513

Zhao L, Brinton RD. Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons. Brain Res 1172:48-59. PMID: 17803971

Brewer GJ, Reichensperger JD, Brinton RD. Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. Neurobiol Aging 27:306-317. PMID: 15961189

Brinton RD, Wang JM Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent. Curr Alzheimer Res 3:185-190. PMID: 16842093

Brinton RD, Wang JM Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease. Curr Alzheimer Res 3:11-17. PMID: 16472197

Chen S, Nilsen J, Brinton RD Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications. Endocrinology 147:5303-5313. PMID: 16916950

Kim MT, Soussou W, Gholmieh G, Ahuja A, Tanguay A, Berger TW, Brinton RD. 17beta-Estradiol potentiates field excitatory postsynaptic potentials within each subfield of the hippocampus with greatest potentiation of the associational/commissural afferents of CA3. Neuroscience 141:391-406. PMID: 16725270

Mannella P, Brinton RD. Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. J Neurosci 26:9439-9447. PMID: 16971528

Morrison JH, Brinton RD, Schmidt PJ, Gore AC Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women. J Neurosci 26:10332-10348. PMID: 17035515

Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. BMC Neurosci 7:74. PMID: 17083736

Nilsen J, Morales A, Brinton RD. Medroxyprogesterone acetate exacerbates glutamate excitotoxicity. Gynecol Endocrinol 22:355-361. PMID: 1684144

Wang JM, Irwin RW, Brinton RD. Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo. Proc Natl Acad Sci U S A 103:16983-16988. PMID: 17077142

Zhao L, Brinton RD. Estrogen Receptor Beta as a Therapeutic Target for Promotion of Neurogenesis and Prevention of Neurodegeneration. Drug Development Research - Special Issue on Estrogens and Neuroprotection 66(2):103-117, 2006

Zhao L, Brinton RD. Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease. BMC Neurosci 7:24. PMID: 16533397

Zhao L, O'Neill K, Brinton RD. Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. J Pharmacol Exp Ther 319:1124-1132. PMID: 16951259

Brinton RD. Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action. Ann N Y Acad Sci 1052:57-74. PMID: 16024751

Nilsen J, Deng J, Brinton RD. Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involved. Drug News Perspect 18:545-553. PMID: 16421627

Wang JM, Johnston PB, Ball BG, Brinton RD. The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression. J Neurosci 25:4706-4718. PMID: 15888646

Wu TW, Wang JM, Chen S, Brinton RD. 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Neuroscience 135:59-72. PMID: 16084662

Zhao L, Brinton RD. Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. J Med Chem 48:3463-3466. PMID: 15887952

Zhao L, Chen S, Ming Wang J, Brinton RD. 17beta-estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: a potential initiation mechanism for estrogen neurotrophism. Neuroscience 132:299-311. PMID: 15802184

Zhao L, O'Neill K, Diaz Brinton R. Selective estrogen receptor modulators (SERMs) for the brain: current status and remaining challenges for developing NeuroSERMs. Brain Res Brain Res Rev 49:472-493. PMID: 16269315

Brinton RD. Requirements of a brain selective estrogen: advances and remaining challenges for developing a NeuroSERM. J Alzheimers Dis 6:S27-35. PMID: 15665410

Brinton RD. Impact of estrogen therapy on Alzheimer's disease: a fork in the road? CNS Drugs 18:405-422. PMID: 15139797

Nilsen J, Brinton RD. Mitochondria as therapeutic targets of estrogen action in the central nervous system. Curr Drug Targets CNS Neurol Disord 3:297-313. PMID: 15379606

O'Neill K, Chen S, Brinton RD. Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease. Exp Neurol 185:63-80. PMID: 14697319

O'Neill K, Chen S, Diaz Brinton R. Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease. Exp Neurol 188:268-278. PMID: 15246826

Zhao L, Brinton RD. Suppression of proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha in astrocytes by a V1 vasopressin receptor agonist: a cAMP response element-binding protein-dependent mechanism. J Neurosci 24:2226-2235. PMID: 14999073

Zhao L, Wu TW, Brinton RD. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Brain Res 1010:22-34. PMID: 15126114

Brinton RD, Nilsen J Effects of estrogen plus progestin on risk of dementia. JAMA 290:1706; author reply 1707-1708. PMID: 14519699

Nilsen J, Brinton RD. Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proc Natl Acad Sci U S A 100:10506-10511. PMID: 12925744

Nilsen J, Diaz Brinton R. Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression. Proc Natl Acad Sci U S A 100:2842-2847. PMID: 12604781

Zhao L, Brinton RD. Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation. J Neurosci 23:4228-4239. PMID: 12764111

Zhao L, Chen S, Brinton RD An estrogen replacement therapy containing nine synthetic plant-based conjugated estrogens promotes neuronal survival. Exp Biol Med (Maywood) 228:823-835. PMID: 12876302

Brinton RD. Selective estrogen receptor modulators (SERM) for the brain: Recent advances and remaining challenges for developing a NeuroSERMTM. Drug Development Research 2002, July 56; 3: 380-92

Brownson EA, Brinton RD, Chambers KC (2002) Vasopressin content in select brain regions during extinction of a conditioned taste aversion. Brain Res Bull 59:125-134. PMID: 12379443

Nilsen J, Brinton RD (2002) Impact of progestins on estradiol potentiation of the glutamate calcium response.Neuroreport 13:825-830. PMID: 11997695

Nilsen J, Brinton RD (2002) Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 143:205-212. PMID: 11751611

Nilsen J, Chen S, Brinton RD (2002) Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway. Brain Res 930:216-234. PMID: 11879813

Zhao L, Brinton RD (2002) Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes. Brain Res 943:117-131. PMID: 12088846

Zhao L, Chen Q, Diaz Brinton R (2002) Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Exp Biol Med (Maywood) 227:509-519. PMID: 12094016

Berger TW, Baudry M, Brinton RD, Liaw J-S, Marmarelis VZ, Yoondong Park A, Sheu BJ, Tanguay Jr. AR  Brain-implantable biomimetric electronics as the next era in neural prosthetics. Proceedings of the IEEE 2001 July; 89(7): 993-1012

Brinton RD. Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges. Learn Mem 8:121-133. PMID: 11390632

Son MC, Brinton RD. Regulation and mechanism of L-type calcium channel activation via V1a vasopressin receptor activation in cultured cortical neurons. Neurobiol Learn Mem 76:388-402. PMID: 11726244

Brinton RD, Chen S. Konjugierte Ostrogene: Werden integritat und function neuronaler zellen erhalten? J für Menopause 2000; 7:16-24. 50

Brinton RD, Chen S, Montoya M, Hsieh D, Minaya J The estrogen replacement therapy of the Women's Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer's disease. Maturitas 34 Suppl 2:S35-52. PMID: 10915920

Brinton RD, Chu HP. Effects neuroprotecteurs des composè estrogéiques des ece. Reproduction Humaine et Hormones 2000; 4:1-11

Brinton RD, Thompson RH, Brownson EA Spatial, cellular and temporal basis of vasopressin potentiation of norepinephrine-induced cAMP formation. Eur J Pharmacol 405:73-88. PMID: 11033316

Chen Q, Patel R, Sales A, Oji G, Kim J, Monreal AW, Brinton RD. Vasopressin-induced neurotrophism in cultured neurons of the cerebral cortex: dependency on calcium signaling and protein kinase C activity. Neuroscience 101:19-26. PMID: 11068133

Chen Q, Schreiber SS, Brinton RD. Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Neuropeptides 34:173-180. PMID: 11021977

Diaz Brinton R, Chen S, Montoya M, Hsieh D, Minaya J, Kim J, Chu HP The women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective. Neurobiol Aging 21:475-496. PMID: 10858597

Brinton RD (1999) A women's health issue: Alzheimer's disease and strategies for maintaining cognitive health. Int J Fertil Womens Med 44:174-185. PMID: 10499738

Davies DL, Bolger MB, Brinton RD, Finn DA, Alkana RL In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol. Psychopharmacology (Berl) 141:339-350. PMID: 10090641

Foy MR, Xu J, Xie X, Brinton RD, Thompson RF, Berger TW   17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. J Neurophysiol 81:925-929. PMID: 10036289

Brinton RD, Yamazaki R, Gonzalez CM, O'Neill K, Schreiber SS Vasopressin-induction of the immediate early gene, NGFI-A, in cultured hippocampal glial cells. Brain Res Mol Brain Res 57:73-85. PMID: 9630527

Brinton RD, Yamazaki RS, Chen Q, Son M Vasopressin action in the mammalian cerebral cortex. Adv Exp Med Biol 449:211-213. PMID: 10026807

Diaz Brinton R. Vasopressin in the mammalian brain: the neurobiology of a mnemonic peptide. Prog Brain Res 119:177-199. PMID: 10074789

Diaz Brinton R, Yamazaki RS Advances and challenges in the prevention and treatment of Alzheimer's disease. Pharm Res 15:386-398. PMID: 9563067

Son MC, Brinton RD. Vasopressin-induced calcium signaling in cultured cortical neurons. Brain Res 793:244-254. PMID: 9630655